Diffusion MR of hyperpolarized 13C molecules in solution.

Hyperpolarized [1,3-13C2 ]ethyl acetoacetate is a novel diagnostic metabolic marker of liver cancer.

An increased prevalence of liver diseases such as hepatitis C and nonalcoholic fatty liver results in an augmented incidence of the most common form of liver cancer, hepatocellular carcinoma (HCC). HCC is most often found in the cirrhotic liver and it can therefore be challenging to rely on anatomical information alone when diagnosing HCC. Valuable information on specific cellular metabolism ca...

In Vivo Monitoring of Rat Spinal Cord Metabolism Using Hyperpolarized Carbon-13 MR Spectroscopic Imaging.

This study demonstrated the feasibility of using hyperpolarized 13C-MR spectroscopic imaging with [1-13C]-pyruvate to evaluate in vivo spinal cord metabolism. High pyruvate and relatively small lactate signal were observed in the cervical spinal cords of naive rats. Lactate and pyruvate measures were similar for spinal cord and supratentorial brain. The results from this study establish baselin...

Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies.

Hyperpolarized 13C MR spectroscopic imaging can detect not only the uptake of the pre-polarized molecule but also its metabolic products in vivo, thus providing a powerful new method to study cellular metabolism. Imaging the dynamic perfusion and conversion of these metabolites provides additional tissue information but requires methods for efficient hyperpolarization usage and rapid acquisitio...

Dynamic Interleaved Imaging of Hyperpolarized Metabolites for Lactate Dehydrogenase Kinetics

INTRODUCTION Dynamic Nuclear Polarization (DNP) of metabolically active 13C-labelled substrates has been reported as a method of generating MR images of in vivo cellular metabolism [1] and hence has the potential to characterize aggressive cancers that exhibit heightened energy metabolism non-invasively[2]. In a phenomenon known as the Warbrug effect, aggressively proliferating tumor cells pref...

Noninvasive Assessment of Renal Tumor Aggressiveness Using Hyperpolarized 13C MR